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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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[Effect of urolithin A on production of interleukins 6 and 10 by immune cells from patients with MS and healthy donors].

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Updated: Jul 11, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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[Multiple sclerosis and melanoma].

N Y Lashch1, A N Boyko1,2, A S Dvornikov1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|November 15, 2023
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) is a progressive autoimmune disease. Patients on disease-modifying therapies (DMDs) have a rare risk of developing melanoma, necessitating dermatological monitoring.

Keywords:
DMTadverse eventsimmunosuppressorsmelanomamonoclonal antibodiesmultiple sclerosis

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Area of Science:

  • Neurology
  • Immunology
  • Dermatology

Background:

  • Multiple sclerosis (MS) is a chronic, autoimmune, demyelinating central nervous system disease primarily affecting young adults.
  • MS presents with diverse neurological symptoms, characterized by periods of exacerbation and remission.
  • Advances in disease-modifying therapies (DMDs) for MS require robust risk management plans to monitor for adverse events and comorbidities.

Approach:

  • This article reviews current literature on the co-occurrence of MS and melanoma.
  • It includes a case report detailing a patient with both conditions.

Key Points:

  • Melanoma is a rare but possible adverse event in patients undergoing treatment for MS with DMDs.
  • The development of melanoma in MS patients necessitates careful monitoring and management.
  • Integrating dermatologists into the multidisciplinary care team is crucial for managing this comorbidity.

Conclusions:

  • The combination of MS and melanoma presents unique challenges in patient management.
  • Proactive dermatological surveillance is essential for MS patients on DMDs.
  • A multidisciplinary approach involving neurology and dermatology improves patient outcomes.