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Unraveling Physical Interactions of Clostridioides difficile with Phage and Phage-Derived Proteins Using In Vitro and
Wichuda Phothichaisri1, Tanaporn Phetruen1,2, Surang Chankhamhaengdecha3
1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Abstract:
Physical interactions between bacteria and phages provide valuable insights into the mechanisms of phage infection and may provide information on the use of phages as a therapeutic approach. In this study, we employed a combination of in vitro and whole-cell assays to examine the interactions between Clostridioides difficile and phages and phage-derived proteins. These techniques can also be adapted for studying the physical interactions between other bacterial species and their associated phages.
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