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Methylglyoxal-induced mutation to 6-thioguanine resistance in V79 cells
Mutation Research
|January 1, 1987
Abstract:
Methylglyoxal, at concentrations ranging from 0.16 to 1.5 mM, caused a dose-dependent increase in the frequency of HGPRT-deficient mutants in V79 cells. Its mutagenic activity was reduced when V79 cells were co-cultured with freshly isolated rat hepatocytes.
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