The Best Psoriasis Medications Emerge
Related Experiment Video
Updated: Jul 11, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Andrew Blauvelt1, Megan H Noe2
1Oregon Medical Research Center, Portland.
Clinical Question:
What are the most effective systemic medications to treat plaque psoriasis?
Bottom Line:
The most effective drugs for psoriasis were infliximab, bimekizumab, ixekizumab, and risankizumab, and the clinical effectiveness was similar when these 4 drugs were compared against one another. No statistically significant differences in serious adverse events were identified in any of the drugs compared with placebo. The main limitations of this meta-analysis include the lack of assessment of clinical effectiveness beyond 52 weeks and the lack of safety assessments for nonserious adverse events.
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