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Additional Impact of Aortic Regurgitation on Left Ventricular Strain and Remodeling in Essential Hypertension

Wei-Feng Yan1, Zhi-Gang Yang1, Xue-Ming Li1

  • 1Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Journal of Magnetic Resonance Imaging : JMRI
|November 15, 2023
PubMed

Insights

Aortic regurgitation (AR) significantly impairs left ventricular (LV) strain and increases LV mass in hypertensive patients. Increasing AR severity correlates with worsening cardiac function and structural changes.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Hypertension Research

Background:

  • Aortic regurgitation (AR) poses a significant risk to cardiac health, particularly in patients with hypertension.
  • Understanding the specific impact of AR on the left ventricle (LV) is crucial for managing hypertensive individuals.

Purpose of the Study:

  • To evaluate left ventricular (LV) strain and structure in hypertensive patients.
  • To determine the relationship between the severity of aortic regurgitation (AR) and LV changes in this population.

Main Methods:

  • A retrospective study involving 263 hypertensive patients and 62 controls, utilizing cardiac MRI.
  • Cardiac MRI with a balanced steady-state free precession (bSSFP) sequence at 3.0T was used to assess LV geometry and strain.
  • AR severity was classified using echocardiography, while LV myocardial strain (GRPS, GCPS, GLPS) and LVMI were quantified via MRI post-processing.

Main Results:

  • Hypertensive patients with AR exhibited significantly reduced LV myocardial strain and elevated LVMI compared to those without AR.
  • A significant negative correlation was observed between AR severity and the absolute values of LV global radial, circumferential, and longitudinal peak strain.
  • The prevalence of LV eccentric hypertrophy significantly increased with escalating AR severity, and AR was identified as an independent factor influencing LV strain and LVMI.

Conclusions:

  • Increasing severity of aortic regurgitation is associated with diminished cardiac function and adverse left ventricular geometric remodeling in hypertensive patients.
  • These findings highlight the detrimental effects of AR on the hypertensive heart and underscore the need for careful monitoring and management.
Abstract

Keywords:
aortic regurgitationhypertensionmyocardial strain

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