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The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey

Shaimaa El-Ashwah1, Jon Salmanton-García2,3, Yavuz M Bilgin4

  • 1Oncology Center, Mansoura University, Mansoura, Egypt.

Leukemia & Lymphoma
|November 15, 2023
PubMed

Insights

COVID-19 infections in chronic myeloid leukemia (CML) patients are generally mild, with low mortality rates. Vaccinations have proven effective in reducing severe infections and improving outcomes for CML patients during the pandemic.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Oncology

Background:

  • COVID-19 significantly impacts patients with hematological malignancies, leading to high hospitalization and mortality rates.
  • Patients with chronic myeloid leukemia (CML) typically have a better prognosis compared to other hematological malignancy patients.

Purpose of the Study:

  • To evaluate the impact of COVID-19 on patients with chronic myeloid leukemia (CML).
  • To assess the effectiveness of vaccinations in mitigating severe infections and mortality among CML patients.

Main Methods:

  • Utilized the large EPICOVIDEHA database of hematological malignancy patients.
  • Analyzed infection severity, hospitalization rates, ICU admissions, and mortality trends in CML patients.

Main Results:

  • The majority of CML patients experienced mild COVID-19 infections.
  • A significant decline in severe and critical infections was observed over time, linked to vaccination.
  • CML patients demonstrated a low mortality rate, with a downward trend in subsequent years.
  • Vaccination effectiveness was confirmed in the CML patient cohort.

Conclusions:

  • Chronic myeloid leukemia patients generally tolerate COVID-19 well, with mild infections being most common.
  • Vaccination strategies have successfully reduced severe COVID-19 outcomes in CML patients.
  • The study confirms the protective role of vaccines in this vulnerable patient population.

Keywords:
COVID-19Chronic myeloid leukemiaSARS-CoV-2neoplasiatirosine kinase inhibitorvaccines

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