Strain differences in the behaviour induced by tryptamine in five strains of mice

The effect of intravenous tryptamine on behaviour was investigated in five strains of mice. Tryptamine at 25 mg/kg induced head weaving and hindlimb abduction in all strains of mice. The intensity of these responses correlated significantly with the content of brain tryptamine. Tryptamine also elicited head twitch and this response was unrelated to the content of brain tryptamine.