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[Hidradenitis suppurativa].

Marcos A González-López1

  • 1Servicio de Dermatología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España; Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Santander, Cantabria, España; Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Cantabria, España; Real Academia de Medicina de Cantabria, Santander, Cantabria, España.

Medicina Clinica
|November 15, 2023
PubMed
Summary
This summary is machine-generated.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition affecting 1% of the population. Its complex causes involve genetics, hormones, and immune factors, leading to significant comorbidities.

Keywords:
Acne inversaAcné inversoChronic inflammationComorbiditiesComorbilidadesEnfermedades inmunomediadasHidradenitis suppurativaHidradenitis supurativaImmune-mediated diseasesInflamación crónica

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory disease originating from the pilosebaceous unit.
  • Affecting approximately 1% of the general population, HS manifests clinically with inflammatory nodules, abscesses, and tunnels in intertriginous areas.
  • The exact etiopathogenesis remains unclear, but it is considered multifactorial, involving genetic, hormonal, environmental, and immunological factors.

Purpose of the Study:

  • To provide a comprehensive overview of hidradenitis suppurativa.
  • To highlight the key clinical characteristics and underlying pathogenetic mechanisms.
  • To emphasize the systemic nature of HS and its associated comorbidities.

Main Methods:

  • Literature review of existing studies on HS.
  • Analysis of clinical presentations and diagnostic criteria.
  • Examination of the role of proinflammatory cytokines (e.g., TNF-α, IL-1β, IL-17) in HS pathogenesis.

Main Results:

  • HS is characterized by specific inflammatory lesions in characteristic body regions.
  • Proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-17, are implicated in HS pathogenesis.
  • HS is increasingly recognized as a systemic disease with significant comorbidities, such as cardiovascular, immune-mediated, and endocrine-metabolic conditions.

Conclusions:

  • HS is a complex, multifactorial inflammatory disease requiring an individualized, patient-centered treatment approach.
  • Management strategies should encompass both medical and surgical modalities.
  • Understanding the systemic nature and comorbidities of HS is crucial for effective patient care.