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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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Sex-specific association between carotid atherosclerosis and fundus arteriosclerosis in a Chinese population: a

Chunxing Liu1, Xiaolong Yang2, Mengmeng Ji1

  • 1Department of Laboratory, Hua Dong Sanatorium, Wuxi, 214065, China.

European Journal of Medical Research
|November 16, 2023
PubMed

Insights

Fundus arteriosclerosis is linked to carotid atherosclerosis in the Chinese population. This association was significant in males but not observed in females, highlighting sex-based differences in vascular disease.

Area of Science:

  • Cardiovascular Medicine
  • Ophthalmology
  • Public Health

Background:

  • Vascular stiffening predicts adverse cardiovascular events.
  • The relationship between microangiopathy (fundus arteriosclerosis) and carotid atherosclerosis is unclear.
  • Investigating this link is crucial for understanding cardiovascular risk.

Purpose of the Study:

  • To examine the association between carotid atherosclerosis and fundus arteriosclerosis.
  • To explore potential sex differences in this relationship.
  • To analyze data from a large Chinese health-examination cohort.

Main Methods:

  • Retrospective cross-sectional study of 20,836 participants (13,050 males, 7786 females).
  • Fundus photography for fundus arteriosclerosis assessment.
  • Color Doppler sonography for carotid atherosclerosis diagnosis.
  • Binary logistic regression analysis.

Main Results:

  • Fundus arteriosclerosis was more prevalent in individuals with carotid atherosclerosis (52.94% vs. 47.06%).
  • Fundus arteriosclerosis showed a significant association with carotid atherosclerosis risk (OR 1.17; 95% CI 1.02-1.34).
  • This association was significant in males (p=0.0005) but not in females (p=0.0746).

Conclusions:

  • Fundus arteriosclerosis is closely associated with carotid atherosclerosis in the Chinese population.
  • The association between fundus and carotid arteriosclerosis differs between sexes.
  • Findings suggest sex-specific risk factors or pathways in vascular aging.
Abstract

Keywords:
Binary logistic regressionCarotid atherosclerosisFundus arteriosclerosisRetinal arteriolesRetrospective cross-sectional study

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