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Published on: December 1, 2016
Nanomedicine Combats Drug Resistance in Lung Cancer
Xiuli Zheng1, Xiaohai Song2, Guonian Zhu1
1Department of Radiology, Department of Respiratory, Huaxi MR Research Center (HMRRC) and Critical Care Medicine, Institute of Respiratory Health, Precision Medicine Center, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, China.
Abstract:
Lung cancer is the second most prevalent cancer and the leading cause of cancer-related death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and radiotherapy are currently available as treatment methods. However, drug resistance is a significant factor in the failure of lung cancer treatments. Novel therapeutics have been exploited to address complicated resistance mechanisms of lung cancer and the advancement of nanomedicine is extremely promising in terms of overcoming drug resistance. Nanomedicine equipped with multifunctional and tunable physiochemical properties in alignment with tumor genetic profiles can achieve precise, safe, and effective treatment while minimizing or eradicating drug resistance in cancer. Here, this work reviews the discovered resistance mechanisms for lung cancer chemotherapy, molecular targeted therapy, immunotherapy, and radiotherapy, and outlines novel strategies for the development of nanomedicine against drug resistance. This work focuses on engineering design, customized delivery, current challenges, and clinical translation of nanomedicine in the application of resistant lung cancer.
Insights
Nanomedicine offers a promising approach to overcome drug resistance in lung cancer treatments. This review explores nanomedicine strategies to enhance precision and efficacy against resistant lung cancer.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Lung cancer is a leading cause of cancer death globally.
- Current treatments like chemotherapy and immunotherapy often fail due to drug resistance.
- Drug resistance significantly impacts treatment outcomes in lung cancer.
Purpose of the Study:
- To review established resistance mechanisms in lung cancer treatments.
- To outline novel nanomedicine strategies for overcoming drug resistance.
- To discuss the potential of nanomedicine in treating resistant lung cancer.
Main Methods:
- Literature review of resistance mechanisms in lung cancer.
- Exploration of nanomedicine applications and engineering designs.
- Analysis of customized delivery systems and clinical translation challenges.
Main Results:
- Identified key resistance mechanisms across various lung cancer therapies.
- Highlighted the potential of multifunctional nanomedicine for precise cancer treatment.
- Discussed strategies for developing effective nanotherapeutics against resistant lung cancer.
Conclusions:
- Nanomedicine presents a highly promising avenue for overcoming lung cancer drug resistance.
- Engineering nanomedicine with tunable properties can improve treatment precision and safety.
- Further research and clinical translation are crucial for realizing nanomedicine's full potential in resistant lung cancer.
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