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Related Experiment Videos

Tremor due to sodium valproate.

N M Hyman, P D Dennis, K G Sinclair

    Neurology
    |August 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Sodium valproate can cause postural tremor, similar to benign essential tremor. Reducing the drug dosage improved tremor in some patients, suggesting a potential biochemical model for essential tremor.

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Essential tremor (ET) is a common neurological disorder with an unknown etiology.
    • Valproate is an anticonvulsant medication with a known side effect profile, but its effect on tremor is not well-characterized.

    Observation:

    • Four patients developed a postural tremor after initiating sodium valproate therapy.
    • The tremor was characterized as similar to "benign essential" tremor and was objectively measured using a variable-capacitance transducer.

    Findings:

    • Sodium valproate dosages ranged from 1000 mg to 2000 mg daily, with serum levels between 34.9 and 154.3 µg/mL.
    • Tremor improved in two patients upon reduction of their sodium valproate dosage.
    • Only one patient had a serum valproate level considered toxic by the laboratory.

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    Implications:

    • Drug-induced tremor, specifically from sodium valproate, may offer a valuable biochemical model for studying essential tremor.
    • This finding suggests that alterations in neurotransmitter systems affected by valproate could play a role in the pathophysiology of essential tremor.