Related Experiment Video
Updated: Jul 11, 2025
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Recent developments in the assessment and management of inflammatory bowel disease in childhood: a narrative review
Zachary Green1,2, Robert Mark Beattie1, James J Ashton1,3
1Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
Insights
Paediatric inflammatory bowel disease (pIBD) management is advancing with new therapies and personalized approaches. Ongoing research is crucial for understanding disease mechanisms and improving patient outcomes in this evolving field.
Area of Science:
- Gastroenterology
- Pediatrics
- Immunology
Background:
- Paediatric inflammatory bowel disease (pIBD) incidence is rising, necessitating updated management strategies.
- Understanding of IBD is evolving, recognizing it as a spectrum of conditions.
- Rapid advancements in monitoring and treatment are transforming pIBD care.
Purpose of the Study:
- To provide an overview of recent advances in paediatric inflammatory bowel disease (pIBD) management.
- To highlight challenges and future directions in pIBD care.
- To focus on sustainable healthcare, personalized therapy, genomics, and novel drugs for pIBD.
Main Methods:
- A narrative review synthesizing research from 2017-2022.
- Structured literature search of PubMed and Medline databases.
- Manual searching of reference lists and compilation of evidence tables for disease outcomes.
Main Results:
- Current pIBD practices integrate clinical guidelines and research, including faecal calprotectin thresholds.
- Specialist investigations like video capsule endoscopy (VCE) and therapeutic drug monitoring are key for disease management.
- Biomarkers and genomic testing are vital for personalizing care and identifying therapeutic targets.
Conclusions:
- Advances in pIBD pathogenesis, genomics, and pharmacology offer new treatment tools.
- Significant challenges remain in understanding disease mechanisms and translating research into practice.
- Further research is essential for optimizing pIBD management and improving patient outcomes.
Background And Objective:
The landscape of paediatric inflammatory bowel disease (pIBD) continues to evolve in an era of increasing incidence. There have been rapid developments in understanding, as we begin to perceive IBD as a spectrum of conditions, alongside advancements in monitoring and treatment. The objective of this article was to provide an overview of recent advances and challenges in the management of pIBD, with a focus on sustainable healthcare, personalised therapy, genomics, new drugs and avenues for future optimisation.
Methods:
We present a narrative review that synthesises and summarises recent research (2017-2022) related to pIBD. We undertook a structured search of the literature (PubMed and Medline) and additional articles were identified through manual searches of reference lists. Evidence tables were compiled for disease outcomes.
Key Content And Findings:
In this review we outline current practice, integrating clinical guidelines and contemporary research. We discuss initial investigations (including suggested threshold for paediatric faecal calprotectin), specialist investigations for disease monitoring [with reference to video capsule endoscopy (VCE) and therapeutic drug levels] and outline new and established treatment options. Biomarkers and genomic testing are examined as important tools for individualising care and identifying potential therapeutic targets, including for top-down therapy. Despite these advances, significant challenges remain, including the need for further research to understand the mechanisms of disease and the translation of these advances into real-world improvements in practice.
Conclusions:
Recent advances in understanding of the pathogenesis of pIBD, alongside genomic and pharmacological developments have added more tools to the armamentarium for the treatment of these conditions and highlighted ongoing areas of research need.
More Related Videos
05:08A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
09:01Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...