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Assessing pediatric anesthesia outcomes and prognostic factors: a comparative study of ketamine vs. ketamine +

Wei Wang1, Weiwei Cai2, Huiying Shao1

  • 1Department of Anaesthesiology, Children's Hospital of Fudan University Shanghai 201102, China.

American Journal of Translational Research
|November 16, 2023
PubMed

Insights

Combining propofol and ketamine offers better pediatric anesthesia outcomes than ketamine alone. This approach improves recovery, reduces adverse events, and lowers the risk of delirium in children.

Area of Science:

  • Anesthesiology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Pediatric anesthesia requires careful consideration of drug combinations for optimal outcomes.
  • Ketamine and propofol are commonly used anesthetic agents in children.
  • Assessing prognostic factors for adverse events in pediatric anesthesia is crucial.

Purpose of the Study:

  • To compare the anesthesia outcomes of ketamine combined with propofol versus ketamine alone in pediatric patients.
  • To identify prognostic factors associated with adverse events, specifically postoperative delirium, in pediatric anesthesia.

Main Methods:

  • Retrospective study of 160 pediatric patients undergoing anesthesia and surgery.
  • Comparison of physiological parameters (SpO2, HR, MAP), recovery time, PACU stay, adverse reactions, and pain scores.
  • Univariate and logistic regression analyses to determine independent risk factors for postoperative delirium.

Main Results:

  • Significant differences in SpO2, HR, and MAP changes between the groups.
  • Combined propofol-ketamine group showed improved recovery time, reduced PACU stay, and fewer adverse reactions.
  • Longer operation time (≥49.5 min) and sole ketamine use were independent risk factors for postoperative delirium.

Conclusions:

  • Combined propofol-ketamine anesthesia provides superior clinical outcomes in children compared to ketamine alone.
  • This combination ensures stable circulation, faster recovery, and reduced incidence of pain, adverse reactions, and delirium.
  • The findings suggest improved pediatric anesthesia prognosis with the combined agent approach.

Keywords:
Ketamineanesthesia outcomespediatric anesthesiaprognostic factorspropofol

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