Vaginal prostaglandin E1 analogue (ONO-802) to soften the cervix in first trimester abortion

Cervical softening by vaginal administration of a prostaglandin E1 analogue (ONO-802) was studied in a double-blind, placebo-controlled study using an objective measure of cervical resistance in 121 women undergoing first trimester induced abortion. Three hours after administration, cervical resistance in control and treated patients did not differ significantly in nulliparous women but did in parous women.