Related Experiment Video
Updated: Jul 11, 2025

Author Spotlight: Characterizing Porous Materials for Aiding the Development of Robust Metal-Organic Frameworks with Adsorption Behavior
Published on: March 8, 2024
Metal-organic framework-derived CoN nanoparticles on N-doped carbon for selective N-alkylation of aniline
Ved Vyas1, Priyanka Maurya1, Arindam Indra1
1Department of Chemistry, Indian Institute of Technology (BHU) Varanasi UP-221005 India arindam.chy@iitbhu.ac.in.
Abstract:
N-alkylation of anilines by alcohols can be used as an efficient strategy to synthesise a wide range of secondary amines. In this respect, a hydrogen borrowing methodology has been explored using precious metal-based catalysts. However, the utilisation of cheap and readily available transition metal based catalysts is required for large-scale applications. In this work, we have reported metal-organic framework-derived CoN@NC catalysts for the selective N-alkylation of anilines with different types of alcohols. The Co-N coordination in CoN@NC was found to be extremely important to improve the conversion efficiency and yield of the product. As a result, CoN@NC produced 99% yield of the desired amines, which is far better than that of Co@C (yield = 65%). In addition, CoN@NC showed remarkable recyclability for six cycles with a minimum drop in the yield of the desired product.
More Related Videos
Related Concept Videos
Preparation of Amines: Reduction of Oximes and Nitro Compounds
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
Preparation of Amines: Reduction of Amides and Nitriles
Amides can be reduced to primary, secondary, and tertiary amines using catalytic hydrogenation, active metals like Fe,...
Aldehydes and Ketones with Amines: Imine and Enamine Formation Overview
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

