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Updated: Jul 11, 2025

Separation of Aldehydes and Reactive Ketones from Mixtures Using a Bisulfite Extraction Protocol
Published on: April 2, 2018
Strategies for chiral separation: from racemate to enantiomer
Jingchen Sui1, Na Wang1,2, Jingkang Wang1,2
1National Engineering Research Center of Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University Tianjin 300072 P. R. China wangna224@tju.edu.cn hongxunhao@tju.edu.cn +86-22-2740-5754.
Abstract:
Chiral separation has become a crucial topic for effectively utilizing superfluous racemates synthesized by chemical means and satisfying the growing requirements for producing enantiopure chiral compounds. However, the remarkably close physical and chemical properties of enantiomers present significant obstacles, making it necessary to develop novel enantioseparation methods. This review comprehensively summaries the latest developments in the main enantioseparation methods, including preparative-scale chromatography, enantioselective liquid-liquid extraction, crystallization-based methods for chiral separation, deracemization process coupling racemization and crystallization, porous material method and membrane resolution method, focusing on significant cases involving crystallization, deracemization and membranes. Notably, potential trends and future directions are suggested based on the state-of-art "coupling" strategy, which may greatly reinvigorate the existing individual methods and facilitate the emergence of cross-cutting ideas among researchers from different enantioseparation domains.
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