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Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Related Experiment Video

Updated: Jul 11, 2025

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
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Published on: March 15, 2024

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Malignant priapism: case report and update on management protocols.

Seyed Sajjad Tabei1, Wesley Baas1, Anthony Brooks2

  • 1Division of Urology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Translational Andrology and Urology
|November 16, 2023
PubMed
Summary

Malignant priapism, a rare condition, requires individualized palliative care. This study suggests penectomy as a last resort for symptom relief in advanced genitourinary cancers.

Keywords:
Priapismcase reportgenitourinary neoplasmmalignant priapismurogenital neoplasm

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Area of Science:

  • Urology
  • Oncology
  • Medical Research

Background:

  • Malignant priapism is a rare condition (approx. 500 cases) caused by neoplasm invasion or metastasis.
  • Established priapism guidelines do not cover malignant cases.
  • This study presents three cases of malignant priapism linked to advanced genitourinary cancers.

Observation:

  • Patients presented with sub-acute penile pain.
  • All patients underwent palliative penectomy.
  • Penectomy provided sustained symptom relief.

Findings:

  • Malignant priapism is associated with poor prognosis, necessitating palliative care.
  • Conventional treatments like shunting may not be effective.
  • Penectomy is a viable last resort for symptom management.

Implications:

  • Individualized treatment plans are crucial for malignant priapism.
  • Current priapism management guidelines require revision.
  • Emphasis on palliative care is essential for these patients.