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One-Step Synthesis of 3-(Fmoc-amino acid)-3,4-diaminobenzoic Acids

Min-Cheng Chien1, Yi Kai Lin1, Yong Liao2

  • 1Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

ACS Omega
|November 16, 2023
PubMed

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Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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