Related Experiment Video
Updated: Jul 11, 2025

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
Published on: August 2, 2024
[Left ventricular dysfunction in patients following high-dose chemotherapy and autologous hematopoietic stem cell
N A Potemkina1, P A Zeynalova1, G D Petrova2
1Sechenov First Moscow State Medical University.
Insights
High-dose chemotherapy and stem cell transplant can impact heart function. A drop in left ventricular global longitudinal strain (GLS) after treatment was linked to higher NT-proBNP levels before the procedure.
Area of Science:
- Cardiology
- Oncology
- Hematology
Aim:
To evaluate the dynamics of LV global longitudinal strain (GLS) and other EchoCG parameters after high-dose chemotherapy (HDCT) and autologous hematopoietic stem cell transplantation (aHSCT).
Material And Methods:
The risk of LV dysfunction in patients after HDCT followed by aHSCT has not been sufficiently studied. This study included 74 patients with hemoblastosis aged 20 to 65 years who had undergone HDCT followed by aHSCT. All patients had a history of antitumor treatment. EchoCG with assessment of LV GLS and measurements of troponin T and N-terminal pro-brain natriuretic peptide (NT-proBNP) were performed for all patients before and after the treatment.
Results:
A decrease in GLS by 15 % or more from the baseline was detected in 6 (8.1 %) patients. The decrease in GLS was associated with increased NT-proBNP >125 pg / ml at baseline (odds ratio, 8.667; 95 % confidence interval, 1.419-52.942; p=0.022).
Conclusion:
The decrease in LV GLS in patients after aHSCT was associated with increased NT-proBNP before the intervention.
More Related Videos
Related Concept Videos
Cardiomyopathy II: Dilated Cardiomyopathy
Heart Failure II: Pathophysiology
Cardiomyopathy V: Interprofessional Care
Pathophysiology of Heart Failure
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
Cardiomyopathy III: Hypertrophic Cardiomyopathy

