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Updated: Jul 11, 2025

Murine Model of CD40-activation of B cells

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

CD40/CD40L expression and its prognostic value in cervical cancer.

G A Grazia^1,2, D R Bastos^1,2, L L Villa^1,2

¹Departamento de Radiologia e Oncologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas

|November 16, 2023

Summary

CD40 and CD40L proteins are highly expressed in squamous cervical carcinomas, offering potential as prognostic markers. This finding suggests improved survival rates for patients with higher expression of these immune-related molecules.

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Murine Model of CD40-activation of B cells

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Published on: March 5, 2010

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Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

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Published on: August 14, 2019

Area of Science:

Immunology
Oncology
Molecular Biology

Background:

CD40, a tumor necrosis factor receptor (TNFR) family member, regulates immune responses and antitumor activity.
CD40 is expressed on various immune and cancer cells, including those in cervical, breast, and melanoma cancers.

Purpose of the Study:

To investigate CD40 and CD40L transcriptional and protein levels in cervical cancer.
To evaluate the association of CD40/CD40L expression with cervical cancer subtypes and patient survival.

Main Methods:

Analysis of CD40/CD40L expression in cervical cancer cell lines and tumor tissues.
Utilizing public datasets to examine CD40/CD40L expression in different cervical tumor subtypes.
Correlating CD40/CD40L expression with overall survival data.

Main Results:

CD40 expression was higher in squamous cell carcinoma cell lines compared to adenocarcinomas.
Approximately 83% of squamous cell carcinomas expressed CD40 in public datasets.
Elevated CD40 and CD40L expression in squamous cervical carcinomas correlated with better overall survival.

Conclusions:

CD40 and CD40L are significantly expressed in squamous cervical carcinomas.
These proteins show potential as prognostic biomarkers for cervical cancer.
Further exploration of CD40/CD40L as prognostic markers in cervical cancer is warranted.