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Elevated plasma peptide YY in human neonates and infants
Pediatric Research
|December 1, 1986
Summary
Neonatal peptide YY (PYY) levels are high at birth and surge postnatally, aiding adaptation to extrauterine life and enteral nutrition. PYY may be a crucial gut hormone for newborn development.
Area of Science:
- Endocrinology
- Neonatal Physiology
- Gastroenterology
Background:
- Peptide YY (PYY) is a gut hormone with known effects on gastrointestinal function.
- Understanding PYY's role in neonates is crucial for infant nutrition and development.
Purpose of the Study:
- To investigate plasma concentrations and molecular forms of PYY in preterm neonates.
- To explore the potential role of PYY in neonatal adaptation to extrauterine life and enteral feeding.
Main Methods:
- Measurement of plasma PYY concentrations in cord blood and at various postnatal days in preterm neonates.
- Comparison of PYY levels with full-term neonates and older infants.
- Gel permeation chromatography to analyze circulating PYY molecular forms.
Main Results:
- Plasma PYY concentrations were significantly higher in cord blood of neonates compared to adults.
- PYY levels surged postnatally in preterm infants, peaking around 12 days of life.
- The primary circulating form of PYY in neonates was the mature 36 amino acid peptide, with evidence of larger precursor molecules.
Conclusions:
- The postnatal surge of PYY in preterm neonates suggests its importance in early adaptation to extrauterine life.
- PYY may play a significant role in facilitating adaptation to enteral nutrition in newborns.
- Further research into PYY's function could inform strategies for neonatal nutritional support.