Related Experiment Video
Updated: Jul 11, 2025

Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides
Published on: June 28, 2024
Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria
Hans Gerstmans1,2, Lisa Duyvejonck1, Roberto Vázquez1
1Department of Biotechnology, Ghent University , Ghent, Belgium.
Importance:
Engineered lysins are considered as highly promising alternatives for antibiotics. Our previous screening study using VersaTile technology identified 1D10 as a possible lead compound with activity against Acinetobacter baumannii strains under elevated human serum concentrations. In this manuscript, we reveal an unexpected mode of action and exceptional thermoresistance for lysin 1D10. Our findings shed new light on the development of engineered lysins, providing valuable insights for future research in this field.
Related Concept Videos
Lytic Cycle of Bacteriophages
Lysogenic Cycle of Bacteriophages
Viral Replication: Lytic Cycle
DNA Bacteriophages
Viral Replication: Lysogenic Cycle
Biological Methods for Microbial Control

