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The Current Challenges in Diagnosing and Treating Malignant Priapism: A Comprehensive Review
I Wayan Yudiana1, Ronald Sugianto2, Putu Eka Dianti Putri3
1Department of Urology, Universitas Udayana, Prof. Dr. I.G.N.G Ngoerah General Hospital, Faculty of Medicine, Bali, Indonesia.
Urology Research & Practice
|November 16, 2023
Summary
Malignant priapism, a persistent erection due to cancer, is unresponsive to standard treatments. Management focuses on palliative care to improve quality of life and relieve symptoms.
Area of Science:
- Urology
- Oncology
- Medical Science
Background:
- Malignant priapism (MP) is a rare condition characterized by persistent penile erection unrelated to sexual stimulation.
- It arises from a neoplastic process affecting the cavernous sinus and efferent veins.
- Established priapism treatments are often ineffective for malignant priapism.
Purpose of the Study:
- To review the therapeutic landscape and outcomes for malignant priapism.
- To highlight the challenges in treating this condition.
Main Methods:
- Review of existing literature on malignant priapism.
- Analysis of various treatment modalities including medication, non-surgical, surgical, and radiotherapy.
Main Results:
- Standard priapism therapies show limited effectiveness in malignant priapism.
- Treatment approaches for MP are diverse, encompassing medication, non-surgical, surgical interventions, and radiotherapy.
- Aggressive multimodal therapy (surgery, radiation, chemotherapy, targeted therapy) yields low survival rates.
Conclusions:
- Malignant priapism presents significant therapeutic challenges with poor survival outcomes.
- Treatment strategies are predominantly palliative, aiming to enhance patient quality of life and alleviate symptoms.
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