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Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
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Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

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Related Experiment Video

Updated: Jun 28, 2026

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
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Periorbital Necrotizing Fasciitis: Case Presentation.

Ryan S Huang1, Nikhil S Patil2, Yasser Khan3

  • 1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Interactive Journal of Medical Research
|November 16, 2023
PubMed
Summary
This summary is machine-generated.

Necrotizing fasciitis (NF), a severe soft tissue infection, can rarely affect the eye socket. This case highlights a young man with periorbital Streptococcus pyogenes NF without typical risk factors.

Keywords:
StreptococcusStreptococcus pyogenes Abacteriabacterialcase reportcase reportsdermatology infectioneyefasciafasciitisfatalinfectioninflammationlife-threateningmusclenecrosisnecrotizingnecrotizing fasciitisorbitorbitalpathologypathophysiologyperiorbitalperiorbital necrotizing fasciitisskin infectionskin reactionsoft tissuesoft tissue infectiontissuetissues

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Area of Science:

  • Infectious Diseases
  • Dermatology
  • Ophthalmology

Background:

  • Necrotizing fasciitis (NF) is a rapidly progressive bacterial infection affecting deep soft tissues.
  • Streptococcus pyogenes is a common cause of NF, typically associated with specific risk factors.

Observation:

  • A rare case of periorbital necrotizing fasciitis caused by Streptococcus pyogenes in a 26-year-old male.
  • The patient presented with no identifiable predisposing risk factors for infection.

Findings:

  • The periorbital location of NF is uncommon and poses unique diagnostic and management challenges.
  • Early recognition and prompt surgical and medical intervention are crucial for favorable outcomes.

Implications:

  • This case expands the understanding of NF presentation, particularly in the periorbital region.
  • Highlights the need for heightened clinical suspicion for NF even in the absence of typical risk factors.