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Updated: Jul 11, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
"Alkene-to-Alkene" Difunctionalization of Enaminones for the Synthesis of Polyfunctionalized Alkenes by
Jingfeng Ye1, Yunyun Liu1, Jin Luo2
1National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China.
Abstract:
The three-component reactions of enaminones, disulfides, and alcohols for the synthesis of polyfunctionalized alkenes have been realized via the C-H and C-N bond transformation on enaminones. The reactions proceed in a novel "alkene-to-alkene" difunctionalization mode without using any transition metal. The application of the alkene products in the synthesis of divergent sulfenyl heteroaryls, including sulfenylated pyrazoles, pyrimidines, and isoxazoles, via simple annulation has also been verified.
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