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Extracellular vesicles on the move: Traversing the complex matrix of tissues
Syrine Arif1, Véronique J Moulin2
1Faculté de Médecine, Université Laval, Quebec City, QC G1V 0A6, Canada; Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC G1S 4L8, Canada; Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Quebec City, QC G1J 1Z4, Canada.
European Journal of Cell Biology
|November 16, 2023
Summary
Extracellular vesicles (EVs) mediate cell communication. Understanding how EVs move through the extracellular matrix is key to developing new therapies and targeting diseases.
Area of Science:
- Biomedical Sciences
- Cell Biology
- Biochemistry
Background:
- Extracellular vesicles (EVs) are crucial for intercellular signaling, transporting biomolecules between cells.
- Research on EVs is expanding due to their potential in health and disease.
- Current studies often neglect the role of the extracellular matrix (ECM) in EV transport.
Conclusions:
- The interaction between EVs and the ECM is fundamental to their biological roles.
- Further research into EV-ECM dynamics will enable more effective therapeutic strategies.
- Targeting specific cells and tissues using EVs requires a comprehensive understanding of their journey through the ECM.
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