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Related Experiment Video

Updated: Jul 11, 2025

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Host-microbe tryptophan partitioning in cardiovascular diseases.

Matteo Antonio Russo1, Enrico Garaci1, Andrea Frustaci1

  • 1University San Raffaele and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele, 00166 Rome, Italy.

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|November 16, 2023
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Summary

Network medicine and multiomics reveal how gut microbes and host interactions, particularly tryptophan metabolism, impact cardiovascular disease. This offers new avenues for precision medicine and nutritional therapies.

Keywords:
Cardiovascular diseasesMetabolitesMicrobiotaOmicsTryptophan metabolism

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Area of Science:

  • Network medicine
  • Systems biology
  • Omics data analysis

Background:

  • Biological processes involve complex molecular interactions.
  • Large-scale omics datasets (genomics, transcriptomics, proteomics, metabolomics, metagenomics, phenomics) are crucial for understanding these interactions.
  • Host-microbe interactions significantly influence cardiovascular health and disease.

Purpose of the Study:

  • To explore host-microbe interactions in cardiovascular diseases using a multiomics network approach.
  • To highlight the role of tryptophan metabolism in orchestrating these interactions.
  • To discuss implications for precision medicine and therapeutic interventions.

Main Methods:

  • Integration of systems biology and network science principles.
  • Utilizing multiomics data (genomics, transcriptomics, proteomics, metabolomics, metagenomics, phenomics).
  • Network-based analysis of molecular components and their interdependencies.

Main Results:

  • Tryptophan metabolism emerges as a key factor in host-microbe interactions within cardiovascular diseases.
  • Multiomics network analysis provides a deeper understanding of these complex relationships.
  • Identified potential targets for precision medicine and novel therapeutic strategies.

Conclusions:

  • A network medicine approach integrating multiomics is essential for understanding complex biological systems like host-microbe interactions in cardiovascular disease.
  • Tryptophan metabolism plays a critical role and presents a promising target for therapeutic interventions.
  • Findings support the development of precision medicine strategies, including nutritional interventions, for cardiovascular diseases.