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Impact of COVID-19 Pandemic on Dispensing of Cardiovascular Drugs in Norway: An Interrupted Time Series Study
Ugochinyere Vivian Ukah1, Robert William Platt2, Hedvig Marie Egeland Nordeng3
1Pregnancy and Child Health Research Center, HealthPartners Institute, Minneapolis, Minnesota; Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University, Montreal, Quebec, Canada.
Insights
The COVID-19 pandemic did not significantly alter cardiovascular drug dispensing trends in Norway. Continued access to these essential medications is crucial for preventing cardiovascular disease complications.
Area of Science:
- Cardiovascular medicine
- Epidemiology
- Public health
Background:
- The COVID-19 pandemic influenced medication use, but its effect on cardiovascular drug dispensing remains unclear.
- Understanding these changes is vital for managing cardiovascular health during public health crises.
Purpose of the Study:
- To analyze the impact of the COVID-19 pandemic on cardiovascular drug dispensing in Norway.
- To assess trends in dispensing before and during the pandemic using a large population-based cohort.
Main Methods:
- Interrupted time series analysis of dispensing data from January 2018 to December 2021.
- Inclusion of adults with and without pre-existing cardiovascular disease.
- Estimation of changes in defined daily dose dispensing rates.
Main Results:
- A pre-pandemic monthly increase in cardiovascular drug dispensing was observed, particularly for individuals with pre-existing conditions.
- The pandemic onset showed a slight, non-significant decrease in dispensing levels.
- Post-pandemic trends indicated a non-significant increase in cardiovascular drug dispensing.
Conclusions:
- The COVID-19 pandemic did not lead to significant shifts in Norwegian cardiovascular drug dispensing patterns.
- Ensuring uninterrupted access to cardiovascular medications is essential for mitigating related morbidity.
Introduction:
The COVID-19 pandemic resulted in changes in prescription patterns and fillings for certain medications, but little is known about its impact on the dispensing of cardiovascular drugs.
Methods:
Trends in dispensing of cardiovascular drugs before and during the pandemic were examined using a population-based cohort in Norway. Using interrupted time series analyses and considering March 1, 2020 as the interruption point, the impact of the pandemic on defined daily dose dispensing of prescribed cardiovascular drugs was estimated in a population of adults with and without pre-existing cardiovascular disease from January 2018 to December 2021. All data were analyzed in 2023.
Results:
In a total of 4,053,957 adults, 690,910 (17.0%) had pre-existing cardiovascular disease. Prior to the pandemic, there was a significant monthly increase in any cardiovascular drug dispensing among those with pre-existing cardiovascular disease (0.30 defined daily dose per month per adult), including prescription of diuretics, calcium channel blockers, and lipid-modifying agents. After controlling for preinterruption trends, there was a slight decrease in level change immediately after the start of the pandemic (2.5 defined daily dose per month per adult) but an increase in the postinterruption trend (0.06 defined daily dose per month per adult) for dispensing of cardiovascular prescriptions, although these changes were not significant.
Conclusions:
Although the COVID-19 pandemic did not appear to result in significant changes in patterns of cardiovascular drug dispensing in Norway, continued access to cardiovascular drugs remains important to prevent further related morbidity.
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