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Modeling the Functional Network for Spatial Navigation in the Human Brain
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Neuron navigators: A novel frontier with physiological and pathological implications.

Parth Sandeep1, Poonam Sharma1, Kanishk Luhach1

  • 1Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, Noida, India.

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Summary
This summary is machine-generated.

Neuron navigators (NAVs) are key proteins for brain development and neuronal functions. Further research is needed to understand their roles in health and disease.

Keywords:
+TIPsAAA ATPaseMicrotubulesNeurite outgrowthNeuritogenesisNeuron navigatorNeuronal migration

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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Developmental Biology

Background:

  • Neuron navigators (NAVs) are microtubule-associated proteins crucial for neurodevelopment.
  • NAV proteins are encoded by NAV genes and are vital for neurite outgrowth and neuronal migration.
  • These proteins are highly expressed in the developing brain and show differential expression across tissues and ages.

Purpose of the Study:

  • To explore the multifaceted roles of neuron navigators in physiological processes.
  • To investigate the involvement of neuron navigators in various pathological conditions.
  • To highlight the need for further research into their functions, modulators, and molecular mechanisms.

Main Methods:

  • Literature review on neuron navigator genes and proteins.
  • Analysis of existing research on NAV functions in neurodevelopment.
  • Examination of studies linking NAVs to diseases.

Main Results:

  • Neuron navigators are implicated in neurodevelopmental processes like neurite outgrowth and cell migration.
  • Dysregulation or altered expression of NAVs is associated with developmental anomalies, neurodegenerative disorders, neuropathic pain, anxiety, cancers, and inflammatory conditions.
  • Current knowledge regarding NAVs' precise functions, regulatory mechanisms, and involvement in disease pathogenesis remains limited.

Conclusions:

  • Neuron navigators play critical roles in normal brain development and function.
  • Their involvement in a wide range of diseases suggests potential as therapeutic targets.
  • Extensive research is required to elucidate the complex roles and mechanisms of neuron navigators.