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Related Experiment Video

Updated: Jul 11, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Complement involvement in sickle cell disease.

Marie-Sophie Meuleman1, Lubka T Roumenina1, Anne Grunenwald2

  • 1Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université Paris Cité, Inflammation, Complement and Cancer team, Paris, France.

Presse Medicale (Paris, France : 1983)
|November 16, 2023
PubMed
Summary
This summary is machine-generated.

Sickle Cell Disease (SCD) involves inflammation and complement system activation, contributing to disease severity. Targeting this system offers potential new therapies for SCD patients.

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Area of Science:

  • Immunology
  • Hematology
  • Pathophysiology

Background:

  • Sickle Cell Disease (SCD) is a genetic blood disorder causing red blood cell sickling and vaso-occlusion.
  • Inflammation is a critical factor in SCD pathophysiology, leading to vascular issues and tissue damage.

Conclusions:

  • The complement system is a significant contributor to SCD pathophysiology.
  • Targeting complement pathways represents a promising therapeutic avenue for managing SCD.
  • Further research into complement inhibition is warranted for SCD management.