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Miscarriage after SARS-CoV-2 vaccination: A population-based cohort study.
Maria P Velez1,2, Deshayne B Fell2,3, Jonas P Shellenberger2
1Department of Obstetrics and Gynaecology, Queen's University, Kingston, Ontario, Canada.
BJOG : an International Journal of Obstetrics and Gynaecology
|November 16, 2023
Summary
SARS-CoV-2 vaccination is not linked to an increased risk of miscarriage. This study in Ontario found no association between COVID-19 vaccines and pregnancy loss, emphasizing vaccine safety for expectant mothers.
Area of Science:
- Reproductive Health
- Vaccinology
- Epidemiology
Background:
- The safety of SARS-CoV-2 vaccination during pregnancy is a critical public health concern.
- Understanding potential risks like miscarriage is essential for informed vaccination decisions.
- Previous studies have yielded mixed results, necessitating further investigation.
Purpose of the Study:
- To assess the association between SARS-CoV-2 vaccination and the risk of miscarriage.
- To account for the competing risk of induced abortion in the analysis.
- To provide robust safety data for COVID-19 vaccines in pregnant individuals.
Main Methods:
- A population-based cohort study was conducted in Ontario, Canada.
- Included were 246,259 pregnant women aged 15-50 years up to 19 weeks gestation.
- Fine-Grey hazard models were used to analyze miscarriage risk, adjusting for confounders and competing risks.
Main Results:
- 34% of pregnant women received at least one SARS-CoV-2 vaccine dose.
- No statistically significant increased risk of miscarriage was observed for vaccinated women (aHR 0.98-1.00).
- Miscarriage rates were similar between unvaccinated, remotely vaccinated, and recently vaccinated groups.
Conclusions:
- SARS-CoV-2 vaccination is not associated with an increased risk of miscarriage.
- The findings support the safety of COVID-19 vaccines for pregnant women.
- The study highlights the need for pregnant women's inclusion in vaccine trials and safety monitoring.
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