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Association Between Days of the Week and Intraocular Pressure: Japan Ningen Dock Study
Ryo Terauchi1, Takashi Wada2, Kota Fukai3
1Department of Ophthalmology.
PréCis:
The analysis of intraocular pressure (IOP) by day of the week using the mega database showed a periodic weekly pattern with the highest value on Monday.
Purpose:
To evaluate IOP by the day of the week.
Patients And Methods:
Annual health checkup examinees between April 2014 and March 2015 were cross-sectionally evaluated. As a result, 655,818 participants [51.5±10.5 (range: 20-96) years, 40.1% women] from 103 medical centers were included. IOP was measured using a noncontact tonometer. The mean IOPs of each day of the week were compared using multiple comparison test and multiple linear regression analysis. Wednesday was set as the reference. Moreover, weekly IOP variations stratified by sex and age were also evaluated.
Results:
Mean IOPs from Monday to Sunday were 13.19±2.97, 13.06±2.92, 13.05±2.91, 13.05±2.92, 13.12±2.94, 13.10±2.96, and 13.16±2.78 mm Hg. IOP was significantly higher on Monday, Friday, and Saturday than those on Wednesday ( P <0.001, <0.001, 0.002). After adjusting for factors affecting IOP, the IOPs on Monday and Saturday were higher than those on Wednesday [β=0.097 (95% CI: 0.074-0.121), P <0.001; β=0.032 (95% CI: 0.005-0.059), P =0.019]. Men had significantly higher IOPs on Monday and Saturday than on Wednesday [β=0.142 (95% CI: 0.110-0.173), P <0.001; β=0.053 (95% CI: 0.017-0.089), P =0.004], whereas women did not have a significant trend. Participants aged below 65 years had higher IOPs on Monday ( P <0.001 in under 60 years; P =0.003 in 60-64 years), while those aged 65 years or older did not ( P =0.856).
Conclusion:
IOP values may have a periodic weekly pattern. The high IOP on Monday was more pronounced in men aged less than 65 years.
Insights
Intraocular pressure (IOP) shows a weekly pattern, with higher levels on Mondays and Saturdays. This trend is more pronounced in men under 65, suggesting a potential link between daily routines and eye pressure.
Area of Science:
- Ophthalmology
- Chronobiology
- Public Health
Background:
- Intraocular pressure (IOP) is a critical factor in glaucoma management.
- Understanding diurnal and weekly variations in IOP is essential for comprehensive eye care.
- Previous studies have suggested diurnal IOP patterns, but weekly variations require further investigation.
Purpose of the Study:
- To investigate the relationship between the day of the week and intraocular pressure (IOP).
- To identify potential weekly patterns in IOP measurements within a large population cohort.
Main Methods:
- A cross-sectional analysis of 655,818 participants from annual health checkups (April 2014-March 2015).
- IOP was measured using a noncontact tonometer across 103 medical centers.
- Statistical analyses included multiple comparison tests and multiple linear regression, with Wednesday as the reference day.
Main Results:
- Mean IOPs varied slightly by day, with significantly higher levels on Monday, Friday, and Saturday compared to Wednesday.
- After adjusting for confounding factors, Monday and Saturday IOPs remained significantly higher than Wednesday.
- Elevated Monday IOP was more pronounced in men and in participants younger than 65 years.
Conclusions:
- Intraocular pressure (IOP) exhibits a discernible weekly pattern, peaking on Mondays and Saturdays.
- The heightened IOP on Mondays is particularly significant in men under 65 years of age.
- These findings suggest that daily or weekly routines may influence IOP, warranting further research into chronophthalmology.
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