Cross-module switching diversity of brain network nodes in resting and cognitive states

Large-scale brain network dynamics reflect state change in brain activities and have potential effects on cognition. Such dynamics can be described by node temporal switching between modules; however, there are only a few studies on the influence of brain network node switching on brain cognition. Based on the functional magnetic resonance imaging (fMRI) data of resting and task states, we constructed dynamic functional networks using overlap sliding-time windows and applied multilayer network analysis to study the behaviours of nodes across brain modules. We found that (i) nodes with a high level switching rate in the resting-state mainly come from the default network, while nodes with a low level of switching rate mainly come from the visual network, (ii) nodes with a high switching rate have lower clustering coefficients and shorter characteristic path lengths, which are mainly affected by the somatomotor network and dorsal attention network; and (iii) in task states, there is still a negative correlation between switching rate, clustering coefficient and characteristic path length. However, the main subsystems that affect brain functions are regulated by the tasks. Our findings not only reveal the relevant characteristics of network node switching behaviours but also provide new insights for further understanding the complex functions of the brain.

The online version contains supplementary material available at 10.1007/s11571-022-09894-z.