Related Experiment Video
Updated: Jul 11, 2025
07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
3.5K
Giant Parathyroid Adenoma: A case Report
Sangeet Kumar Agarwal1, Uday Monga2, Shiv Chadha3
1Head and Neck Oncosurgery, Sir Ganga Ram Hospital Sir Ganga Ram Hospital Marg, New Delhi, 110060 India.
Summary
Giant parathyroid adenoma, a rare cause of primary hyperparathyroidism, can lead to severe complications. This case highlights the successful surgical removal of a large adenoma in a young woman, normalizing parathyroid hormone levels.
Area of Science:
- Endocrinology
- Surgical Oncology
- Nephrology
Background:
- Giant parathyroid adenoma (GPA) is defined as a parathyroid tumor weighing over 3.5g, significantly larger than typical adenomas.
- GPAs primarily cause primary hyperparathyroidism and can present with severe complications like acute pancreatitis and kidney injury.
- Young individuals can be affected, necessitating prompt diagnosis and management.
Purpose of the Study:
- To report an interesting case and clinical course of a young woman diagnosed with a giant parathyroid adenoma.
- To illustrate the diagnostic process and successful management of a rare GPA case.
- To emphasize the importance of considering GPA in young patients with hypercalcemia and related complications.
Main Methods:
- A 30-year-old female presented with symptoms of acute pancreatitis and acute kidney injury.
- Diagnostic workup included biochemical tests revealing hypercalcemia and hyperparathyroidism, neck ultrasonography, and a 99mTc-Sestamibi parathyroid scan.
- The patient underwent successful minimally invasive parathyroidectomy for left parathyroid adenoma excision.
Main Results:
- Preoperative parathyroid hormone (PTH) levels were markedly elevated at 1900 pg/ml.
- Imaging confirmed a large left parathyroid adenoma measuring 50x24x29 mm.
- Postoperatively, PTH levels significantly decreased to 242 pg/ml, indicating successful adenoma removal.
Conclusions:
- Giant parathyroid adenoma is a rare but significant cause of primary hyperparathyroidism, even in young patients.
- Minimally invasive parathyroidectomy is an effective treatment for GPA, leading to biochemical normalization.
- Prompt diagnosis and surgical intervention are crucial for managing GPA and preventing severe complications.
