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Updated: Jul 11, 2025
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Histopathological Pattern of Head and Neck Recurrent BCC After Previous Cryotherapy
Fábio Muradás Girardi1, Antônio Augusto de Carvalho Neto2, Manoela Domingues Martins3,4
1Integrated Oncology Center of Ana Nery Hospital, Pereira da Cunha Street, 209, 96835090 Santa Cruz do Sul, Brazil.
Abstract:
Surgical resection is the gold standard treatment for basal cell carcinomas, although there is literature supporting cryotherapy for low-risk cases. Our aim was to compare the histopathological aspects of recurrent postcryotherapy head and neck cutaneous BCC with de novo tumors, using a case-control study. 51 Recurrent postcryotherapy cases were selected between January 2017 and December 2021 and compared to 132 controls filtered from a consecutive series of de novo head and neck cutaneous BCC operated between January and December 2021. Aggressive variants, multifocality, invasion beyond adipose tissue and higher Clark levels were associated with recurrent cases on multivariate analysis. Previous cryotherapy treatment may have contributed to an increased risk of more aggressive recurrent disease and caution using this treatment modality is advised.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s12070-023-03919-7.
