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Updated: Jul 11, 2025

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Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
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Nanobiosensing with graphene and carbon quantum dots: Recent advances
Brandon K Walther1,2, Cerasela Zoica Dinu3, Dirk M Guldi4
1Biosensors and Biochips (C3), Department of Biomedical Engineering and Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
Summary
Graphene and carbon quantum dots (GQDs and CQDs) are advanced nanomaterials revolutionizing biosensing. Their unique properties enhance analyte detection in biotransducers and biosensors for quality and safety applications.
Area of Science:
- Nanomaterials Science
- Biotechnology
- Analytical Chemistry
Background:
- Graphene quantum dots (GQDs) and carbon quantum dots (CQDs) are novel nanomaterials with unique quantum properties and biocompatibility.
- These materials are increasingly utilized in biosensing for analyte detection and monitoring, combining molecular recognition with signal transduction.
Purpose of the Study:
- To review recent advancements in biotransducers and biosensors utilizing GQDs and CQDs.
- To highlight how these nanomaterials interface with biomolecules for improved analyte detection.
- To provide insights into functional biotransducer design and future research directions.
Main Methods:
- Literature survey focusing on research from the last 5 years.
- Analysis of GQD and CQD properties relevant to biosensor design.
- Discussion of nano-enabled biotransducers and various biosensing configurations.
Main Results:
- GQDs and CQDs significantly advance biosensing capabilities.
- These nanomaterials enhance molecular recognition and signal transduction for superior analyte detection.
- Recent progress shows creative applications in developing sensitive and specific biosensors.
Conclusions:
- Graphene quantum dots and carbon quantum dots are pivotal in developing next-generation biosensors.
- Further research guided by this review can enhance biosensor design for quality and safety.
- This work serves as a foundational guide for GQD- and CQD-based biosensor development.

