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Implant Survival in Tissue-Engineered Mandibular Reconstruction-Early Experiences
Victoria A Mañón1, Nicholas Oda1, Emeric Boudreaux1
1Bernard and Gloria Pepper Katz, Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Craniomaxillofacial Trauma & Reconstruction
|November 17, 2023
Summary
Dental implants placed in tissue-engineered bone show a 91.3% survival rate, offering a predictable option for orofacial rehabilitation after benign pathology resection.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Mandibular reconstruction presents challenges for dental implant placement.
- Tissue engineering offers novel solutions for bone regeneration.
Purpose of the Study:
- To evaluate early outcomes of dental implants in regenerated bone.
- To assess the prognosis of implants in tissue-engineered mandibular reconstructions.
Main Methods:
- Retrospective evaluation of 12 patients with mandibular resection and reconstruction.
- Reconstruction used bone marrow aspirate concentrate (BMAC), recombinant human bone morphogenic protein-2 (rhBMP-2), and allogeneic bone.
- Implant success defined by osseointegration, absence of radiolucency, and infection.
Main Results:
- 46 implants were placed in 12 patients; overall survival rate was 91.3%.
- 4 implant failures occurred in 2 patients without known risk factors.
- Average implant placement was 11.6 months post-reconstruction.
Conclusions:
- Dental implants in tissue-engineered bone are a predictable option for orofacial rehabilitation.
- This approach provides a viable solution for large bony defects post-benign pathology resection.
