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Updated: Jul 11, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Synthesis of acyl fluorides through deoxyfluorination of carboxylic acids
Mengjie Cen1, Xi Yang1, Shanshan Zhang1
1Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemical, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou, 570228, China. hainanliulong@hainanu.edu.cn.
Abstract:
A direct deoxyfluorination of carboxylic acids by utilizing inorganic potassium fluoride (KF) as a safe and inexpensive fluoride source has been developed. Both aryl carboxylic acids and cinnamyl carboxylic acids could be efficiently transformed into valuable acyl fluorides in moderate to high yields with good functional group tolerance. A scale-up reaction could be carried out smoothly under solvent-free conditions, which further demonstrated the practicality of this reaction in organic synthesis.
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