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Updated: Jul 11, 2025
09:58
Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
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Visible light-mediated halogenation of organic compounds
Alexey A Festa1, Olga A Storozhenko1, Leonid G Voskressensky1
1Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya st. 6, Moscow, 117198, Russian Federation. erik.vandereycken@kuleuven.be.
Chemical Society Reviews
|November 17, 2023
Summary
Visible light photoredox catalysis offers a sustainable approach to organic synthesis, particularly for creating and utilizing halogenated compounds. This review explores its impact on halogenation and halofunctionalization reactions.
Area of Science:
- Organic Chemistry
- Sustainable Chemistry
- Photocatalysis
Background:
- Halogenated compounds are essential intermediates and final products in pharmaceuticals, agrochemicals, and materials science.
- Traditional halogenation methods can be harsh or inefficient.
- Visible light photoredox catalysis presents a milder, more sustainable alternative.
Purpose of the Study:
- To review the significant impact of visible light-promoted chemistry on halogenation reactions.
- To summarize advancements in visible light-driven halofunctionalization of organic molecules.
Main Methods:
- Photoredox catalysis using visible light irradiation.
- Exploration of various organic substrates and halogen sources.
- Analysis of reaction mechanisms and scope.
Main Results:
- Demonstration of efficient and selective halogenation and halofunctionalization reactions.
- Highlighting the versatility of visible light catalysis in C-X bond formation.
- Showcasing sustainable synthetic routes to valuable halogenated compounds.
Conclusions:
- Visible light photoredox catalysis is a powerful and sustainable tool for modern organic synthesis.
- It enables novel and efficient methods for halogenation and halofunctionalization.
- This approach is crucial for drug discovery and materials science applications.
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