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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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Updates in Management of Malignant Pleural Mesothelioma

Alexius John1, Hazel O'Sullivan2,3, Sanjay Popat2,4

  • 1The Lung Unit, The Royal Marsden Hospital, London, UK. alexiusjohn2305@gmail.com.

Current Treatment Options in Oncology
|November 17, 2023
PubMed
Abstract

Insights

Malignant pleural mesothelioma (MPM) treatment is evolving. Immune checkpoint inhibitors are now standard for unresectable MPM, with ongoing research into genomic therapies for relapsed disease.

Area of Science:

  • Oncology
  • Thoracic Surgery
  • Medical Oncology

Background:

  • Malignant pleural mesothelioma (MPM) is an aggressive, asbestos-associated thoracic cancer with limited curative options.
  • Surgical resection has shown limited survival benefit in MPM management.
  • Previous first-line treatment for unresectable MPM involved platinum-pemetrexed chemotherapy with bevacizumab.

Purpose of the Study:

  • To overview current treatment strategies for malignant pleural mesothelioma.
  • To highlight the evolving landscape of MPM therapeutics.
  • To discuss patient selection for optimal treatment strategies.

Main Methods:

  • Review of landmark phase 3 clinical trials.
  • Analysis of current first-line and relapsed disease treatment approaches.
  • Discussion of emerging genomic-based therapies.

Main Results:

  • Immune checkpoint inhibitors (CPIs) are now established in the upfront management of unresectable MPM.
  • CPI regimens include nivolumab-ipilimumab or carboplatin-pemetrexed-pembrolizumab.
  • Novel genomic-based therapies targeting tumor suppressor gene aberrations are under evaluation for relapsed MPM.

Conclusions:

  • The treatment paradigm for MPM has shifted towards immunotherapy.
  • Optimizing patient selection for specific therapeutic strategies is crucial.
  • Future MPM therapeutics show promise with ongoing research and development.
Keywords:
ChemoimmunotherapyGenomic driven therapyMesotheliomaPeri-operative therapyRadiotherapySurgery

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