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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Pericarditis II: Clinical Features and Diagnostic Tests01:19

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Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
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Characteristics of Interstitial Pneumonia With Autoimmune Features (IPAF): Protocol for a Multicenter Prospective

Patrycja Rzepka-Wrona1, Szymon Skoczyński2, Wojciech J Piotrowski3

  • 1Department of Pneumonology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

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|November 17, 2023
PubMed
Summary

This study characterizes Polish patients with Interstitial Pneumonia with Autoimmune Features (IPAF), comparing them to other interstitial lung diseases. It also seeks biomarkers in serum and bronchoalveolar lavage fluid for improved understanding of IPAF.

Keywords:
CTDIPAFconnective tissue diseaseidiopathic interstitial pneumoniainterstitial lung diseaseinterstitial pneumonia with autoimmune featureslung diseasepneumoniaradiologyrespiratory

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Area of Science:

  • Pulmonology
  • Immunology
  • Biomarker Discovery

Background:

  • Interstitial lung disease (ILD) is a diverse group of lung diseases.
  • Interstitial pneumonia with autoimmune features (IPAF) is a recently defined subtype associated with autoimmunity.

Purpose of the Study:

  • To characterize Polish patients with IPAF.
  • To compare IPAF patients with other ILD cohorts.
  • To identify prognostic and diagnostic biomarkers in serum and bronchoalveolar lavage fluid (BALF).

Main Methods:

  • Multicenter prospective study with 240 participants (1 IPAF group, 2 ILD control groups).
  • Analysis of radiological (HRCT) and functional (6MWT, PFT) parameters.
  • Measurement of cytokine levels (IL-8, TGF-β1, CXCLs, SP-A, SP-D, MUC5AC, CHI3L1) in serum and BALF.
  • Assessment of quality of life, dyspnea, cough, anxiety, and depression.

Main Results:

  • Patient recruitment begins October 2023; final results expected in 2028.
  • Preliminary results anticipated within 2-3 years.
  • Comparative analysis of IPAF patients versus idiopathic ILDs and CTD-ILDs will be performed.

Conclusions:

  • This research will advance the understanding of IPAF pathogenesis and clinical outcomes.
  • Identification of biomarkers may aid in diagnosis and prognosis.