Management of pediatric toxic ingestions in the emergency department

Mia Kanak1, Stacy Tarango2, Deborah R Liu3

  • 1Assistant Professor of Clinical Pediatrics, Division of Emergency and Transport Medicine, Children's Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA.

PubMed

Insights

Pediatric ingestions are a common emergency room challenge. This review covers current resuscitation, diagnosis, and treatment strategies for common childhood poisonings, including decontamination and antidotes.

Area of Science:

  • Emergency Medicine
  • Pediatric Toxicology

Background:

  • Pediatric ingestions pose diagnostic and management challenges for emergency clinicians.
  • Timely identification of ingested substances can be difficult despite various diagnostic tools.
  • Management strategies and recommendations for pediatric poisonings are continually evolving.

Purpose of the Study:

  • To review the initial resuscitation, diagnosis, and treatment of common pediatric ingestions.
  • To discuss current recommendations for decontamination procedures.
  • To provide guidance on the administration of antidotes for specific toxins.

Main Methods:

  • Literature review of common pediatric ingestions.
  • Synthesis of current guidelines for emergency management.
  • Discussion of diagnostic approaches including physical examination, ECG, labs, and imaging.

Main Results:

  • The review synthesizes current approaches to pediatric ingestions.
  • It highlights diagnostic difficulties and evolving treatment controversies.
  • It provides updated recommendations for resuscitation, diagnosis, and treatment.

Conclusions:

  • Effective management of pediatric ingestions requires a comprehensive understanding of current evidence.
  • Prompt diagnosis and appropriate treatment, including decontamination and antidotes, are crucial.
  • This review offers a valuable resource for emergency clinicians managing pediatric poisonings.

Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
830
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
521
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
884
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
465
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
983
Antidotes01:17

Antidotes

Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
653