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Related Experiment Videos

Venous clots: evaluation with MR imaging.

S Rapoport, H D Sostman, C Pope

    Radiology
    |February 1, 1987
    PubMed
    Summary
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    Magnetic resonance imaging (MRI) can differentiate blood clots from surrounding tissues. This study shows MRI can also help determine the age of venous thrombi by analyzing proton relaxation times.

    Area of Science:

    • Biomedical Imaging
    • Vascular Biology
    • Medical Physics

    Background:

    • Static blood and venous thrombi exhibit distinct proton relaxation and imaging properties.
    • Differentiating intravascular clot from adjacent soft tissues is crucial for diagnosis.
    • Understanding the aging process of thrombi can inform treatment strategies.

    Purpose of the Study:

    • To evaluate magnetic resonance imaging (MRI) characteristics of static blood and canine venous clots.
    • To assess the efficacy of different MRI sequences in visualizing intravascular thrombi.
    • To investigate the correlation between clot age and proton relaxation times (T1 and T2).

    Main Methods:

    • In vitro and in vivo studies were conducted using canine jugular veins.
    • Proton relaxation times (T1 and T2) were quantitatively measured.

    Related Experiment Videos

  • Two inversion recovery sequences with short inversion time (100 msec) and standard T1- and T2-weighted sequences were employed.

    • Main Results:

    • Short inversion time inversion recovery (STIR) sequences showed superior differentiation of clot from soft tissues compared to standard sequences.
    • Acute clot exhibited significantly reduced T1 and T2 relaxation times compared to stagnant blood.
    • Both T1 and T2 relaxation times decreased as the clot aged.

    Conclusions:

    • Specific MRI sequences can effectively distinguish intravascular thrombi from surrounding tissues.
    • Proton relaxation times of venous thrombi change with age.
    • MRI holds potential for determining the age of venous thrombi, aiding clinical assessment.