Improving the temporal resolution of event-based electron detectors using neural network cluster analysis
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Updated: Jul 11, 2025

Automated Detection and Analysis of Exocytosis
Published on: September 11, 2021
Alexander Schröder1, Christopher Rathje2, Leon van Velzen3
1Institute of Physics, University of Oldenburg, Oldenburg, Germany; Department of Physics, University of Regensburg, Regensburg, Germany.
Abstract:
Novel event-based electron detector platforms provide an avenue to extend the temporal resolution of electron microscopy into the ultrafast domain. Here, we characterize the timing accuracy of a detector based on a TimePix3 architecture using femtosecond electron pulse trains as a reference. With a large dataset of event clusters triggered by individual incident electrons, a neural network is trained to predict the electron arrival time. Corrected timings of event clusters show a temporal resolution of 2 ns, a 1.6-fold improvement over cluster-averaged timings. This method is applicable to other fast electron detectors down to sub-nanosecond temporal resolutions, offering a promising solution to enhance the precision of electron timing for various electron microscopy applications.

