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Updated: Jul 11, 2025

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
Published on: April 17, 2017
Ventilatory failure in chronic neuromuscular disease
Gabriella Heloise Long1, Andrew Bentley2,3, Mark Roberts2,4
1North West Ventilation Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK gabriella.long1@nhs.net.
Abstract:
Patients with neuromuscular diseases (NMD) can present to the neurologist with symptoms and signs of respiratory failure, either acutely or as an insidious process in the outpatient setting. Since the advent of non-invasive ventilation, the outcomes of patients with ventilatory failure due to NMD have dramatically improved. However, the natural history of different NMDs requires a nuanced approach to respiratory investigation and management. Respiratory failure dictates the prognosis of many NMDs and timing the most appropriate investigation and referral to ventilation services is crucial in optimising care.
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