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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Replicative Cell Senescence02:15

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Updated: Jul 11, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
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Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

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Senotherapy, cancer, and aging.

Lodovico Balducci1, Claire Falandry2, Silvio Monfardini3

  • 1Senior Member Emeritus Moffitt Cancer Center, Tampa, FL, USA.

Journal of Geriatric Oncology
|November 17, 2023
PubMed
Summary
This summary is machine-generated.

Senotherapy, which eliminates aging cells, shows promise in preventing and treating cancer in older adults. This approach may reduce cancer incidence, improve treatment tolerance, and prevent recurrence.

Keywords:
Cancer in the older patientChemotherapySenolysisSenomorphic therapySenotherapy

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Area of Science:

  • Gerontology and Oncology
  • Cellular Senescence
  • Cancer Biology

Background:

  • Cellular senescence is a state where cells stop dividing and exhibit a senescence-associated secretory phenotype (SASP).
  • The SASP contributes to aging-associated diseases and disabilities, including cancer.
  • Senescent cells, such as fibroblasts and adipose cells, play a role in aging.

Purpose of the Study:

  • To review the effects of senotherapy on cancer prevention and treatment in older individuals.
  • To explore the potential of eliminating senescent cells to combat cancer.

Main Methods:

  • A narrative review based on a Medline search using keywords: senotherapy, senolysis, and senomorphic agents.
  • Analysis of findings from cell cultures, murine models, and ongoing clinical trials.

Main Results:

  • Several agents (metformin, rapamycin, dasatinib, quercetin, fisetin, etc.) can eliminate senescent cells.
  • Senotherapy has shown potential in prolonging lifespan and decreasing cancer incidence in animal models.
  • Senescent tumor cells are implicated in tumor recurrence and treatment resistance.

Conclusions:

  • Senotherapy may significantly impact cancer management by reducing cancer incidence and aggressiveness.
  • It holds potential for improving tolerance to cancer treatments and preventing relapse.
  • Senotherapy could also ameliorate chemotherapy-induced complications.