Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Survival Analysis01:21

Cancer Survival Analysis

356
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
356
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of Non-Invasive Brain Stimulation in Alzheimer's Disease: An Umbrella Review of Meta-Analyses.

Neuroscience and biobehavioral reviews·2026
Same author

Foundation Models in Cancer Pathology: Techniques, Applications, and Future Directions.

Research (Washington, D.C.)·2026
Same author

Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization.

Frontiers in immunology·2026
Same author

Evaluation of Preoperative Tamsulosin Use in Ureteroscopic Holmium Laser Lithotripsy for Elderly Patients with Ureteral Stones.

Journal of visualized experiments : JoVE·2026
Same author

Characterization of gut microbiome signatures in metabolic dysfunction associated steatotic liver disease.

NPJ biofilms and microbiomes·2026
Same author

Methylation plus alpha-fetoprotein blood test for early detection of HCC in at-risk populations.

Hepatology communications·2026

Related Experiment Video

Updated: Jul 10, 2025

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence
08:08

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Published on: June 10, 2025

59

Big data and artificial intelligence in cancer research.

Xifeng Wu1, Wenyuan Li2, Huakang Tu3

  • 1Department of Big Data in Health Science, School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; National Institute for Data Science in Health and Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Trends in Cancer
|November 17, 2023
PubMed
Summary
This summary is machine-generated.

This review examines how large-scale data sets and machine learning are transforming cancer studies. It highlights current methods for combining diverse information types, addresses existing technical hurdles, and discusses how these tools can improve patient care.

Keywords:
artificial intelligencebig datacancerdata fusionplatformprecision medicinemachine learningcomputational biologyprecision medicinedata fusion

Frequently Asked Questions

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

4.8K

Related Experiment Videos

Last Updated: Jul 10, 2025

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence
08:08

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Published on: June 10, 2025

59
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

4.8K

Area of Science:

  • Oncology research within big data analytics
  • Artificial intelligence applications in clinical medicine

Background:

The integration of massive datasets into oncology remains hindered by significant technical obstacles. Prior research has shown that computational tools offer potential for processing complex biological information. That uncertainty drove the need for a clearer synthesis of current methodologies. No prior work had resolved how to effectively harmonize diverse data streams for clinical benefit. Existing frameworks often struggle with the sheer volume of information generated by modern diagnostic platforms. This gap motivated a closer look at the intersection of machine learning and tumor biology. Scholars have identified that current curation practices frequently lack the standardization required for widespread adoption. Understanding these systemic barriers is necessary to move beyond preliminary experimental models.

Purpose Of The Study:

The aim of this review is to provide a comprehensive overview of the current state of the art in computational analysis for cancer research. This work seeks to clarify how large-scale information sets are currently utilized in the field. The authors intend to highlight key applications that demonstrate the potential of these digital tools. They also address the persistent challenges that hinder the effective implementation of these technologies. By sketching the current landscape, the study strives to foster a deeper understanding among researchers. The authors aim to facilitate the advancement of data utilization practices in clinical settings. They issue a call for interdisciplinary collaborations to solve complex analytical problems. Ultimately, the work intends to contribute to improved patient outcomes through better technological integration.

Main Methods:

The review approach involved a systematic survey of contemporary computational strategies within the cancer field. Authors evaluated existing literature to identify trends in information processing and machine learning integration. This assessment focused on how researchers currently manage and interpret large-scale biological repositories. The investigation utilized a comparative lens to contrast traditional analytical techniques with emerging digital methodologies. Reviewers synthesized findings regarding the efficacy of various data fusion platforms. They examined documented hurdles that impede the seamless adoption of these advanced technologies. The study design prioritized identifying gaps in current curation and utilization workflows. This methodology provided a structured overview of the evolving landscape in digital cancer science.

Main Results:

Key findings from the literature indicate that the field has experienced an extraordinary surge in the application of advanced computational tools. The authors report that modern development has successfully enabled the fusion of multiscale and multimodal information streams. Results demonstrate that extracting meaningful insights from complex repositories is now a rapidly evolving process. The review identifies that significant challenges persist regarding the efficiency of current curation practices. Findings reveal that in-depth analysis remains constrained by existing technical limitations in data handling. The evidence suggests that these computational frameworks are essential for achieving a profound understanding of tumor biology. Authors highlight that current efforts are primarily directed toward overcoming these systemic analytical barriers. The literature confirms that these digital advancements are actively shaping the future of oncological research.

Conclusions:

The authors propose that interdisciplinary cooperation is necessary to overcome existing technical barriers in data management. Their synthesis suggests that refined curation practices will enhance the utility of computational models in clinical settings. The review implies that merging diverse data types provides a more complete picture of tumor progression. Researchers indicate that current advancements are shifting the paradigm toward more personalized therapeutic strategies. They emphasize that addressing analytical limitations is a prerequisite for translating digital insights into bedside care. The evidence points toward a future where automated systems assist in complex diagnostic decision-making processes. The authors conclude that ongoing refinement of these tools will likely yield better prognostic accuracy for patients. This work serves as a call to action for integrating computational expertise into standard oncological practice.

The researchers propose that combining multiscale and multimodal information streams allows for more robust pattern recognition. Unlike traditional single-source analysis, this integrated approach captures complex biological interactions that are otherwise invisible to standard statistical methods.

The authors highlight data curation as a primary hurdle. While raw information is abundant, the lack of standardized, high-quality preparation protocols prevents the effective deployment of predictive models compared to well-curated, smaller-scale clinical trials.

The authors suggest that interdisciplinary collaboration is necessary to bridge the gap between computational science and clinical oncology. Without this synergy, technical experts may develop tools that lack biological relevance, whereas clinicians may struggle to interpret complex algorithmic outputs.

The authors describe multiscale data as a vital component for capturing tumor heterogeneity. By integrating molecular, imaging, and clinical records, these models provide a more comprehensive view than relying on a single data type alone.

The researchers identify the current state of the art as a rapidly evolving landscape. They compare this to earlier, more limited analytical approaches, noting that modern systems now handle vastly larger volumes of information with greater speed.

The authors propose that these advancements will contribute to improved patient outcomes. They suggest that by refining how information is extracted and utilized, clinicians can move toward more precise, individualized treatment plans for better long-term survival.