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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Related Experiment Video

Updated: Jul 10, 2025

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury
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Intervertebral Disk Degeneration and Bone Mineral Density: A Bidirectional Mendelian Randomization Study.

Jie Zhao1, Jingyu Wang1, Haixu Xu2

  • 1Department of Clinical Lab, Tianjin First Central Hospital, 300192, Tianjin, China.

Calcified Tissue International
|November 17, 2023
PubMed
Summary

Lower bone mineral density (BMD) causally increases the risk of intervertebral disk degeneration (IVDD). Specifically, heel, total body, femoral neck, and lumbar spine BMD significantly impact IVDD development, with no evidence of IVDD affecting BMD.

Keywords:
Bone mineral densityGenome-wide association studyIntervertebral disk degenerationMendelian randomizationOsteoporosis

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Area of Science:

  • Genetics
  • Orthopedics
  • Epidemiology

Background:

  • Intervertebral disk degeneration (IVDD) is a significant cause of low back pain.
  • Bone mineral density (BMD) is a key indicator of skeletal health.
  • The causal relationship between BMD and IVDD remains incompletely understood.

Purpose of the Study:

  • To investigate the bidirectional causal relationship between BMD and IVDD.
  • To determine if genetic predisposition to lower BMD influences IVDD risk.
  • To assess if genetic predisposition to IVDD influences BMD.

Main Methods:

  • Two-sample bidirectional Mendelian randomization analysis.
  • Utilized summary-level data from large-scale Genome-Wide Association Studies (GWAS).
  • Employed inverse variance weighting (IVW) and sensitivity analyses, with myopia as a negative control.

Main Results:

  • Significant causal effects of BMD on IVDD were identified for heel, total body, femoral neck, and lumbar spine.
  • Lower BMD (heel, total body, femoral neck, lumbar spine) was found to causally increase the risk of IVDD.
  • No significant causal effect of IVDD on BMD was detected.

Conclusions:

  • This study provides strong evidence for a causal effect of reduced BMD on the development of IVDD.
  • Specific BMD measures (heel, total body, femoral neck, lumbar spine) are significant causal factors for IVDD.
  • The findings suggest that interventions targeting BMD may be beneficial in preventing or managing IVDD.