Related Experiment Video
Updated: Jul 10, 2025
Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
Published on: April 21, 2022
The risk factors involved in airway mucus plug in children with ADV Pneumonia
Jing-Jing Huang1, Lin Yuan1, Zhi-Qiang Zhuo1
1Department of Infection, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), NO.92 Yibin Road, Huli District, Xiamen, 361006, Fujian, China.
Insights
Prolonged fever, elevated procalcitonin (PCT), and high lactate dehydrogenase (LDH) levels are key indicators for mucus plugs in children with adenovirus (ADV) pneumonia. Identifying these risk factors aids in early diagnosis and management.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Critical Care Medicine
Background:
- Adenovirus (ADV) pneumonia is a significant respiratory illness in children.
- Mucus plugging is a serious complication that can lead to airway obstruction.
- Understanding risk factors for mucus plugs in ADV pneumonia is crucial for timely intervention.
Purpose of the Study:
- To identify the risk factors associated with mucus plug formation in children diagnosed with ADV pneumonia.
- To analyze clinical, laboratory, and imaging data to determine predictors of mucus plugging.
Main Methods:
- Retrospective analysis of pediatric patients with ADV pneumonia from September 2018 to September 2021.
- Comparison of patients with and without mucus plugs (39 vs. 53 cases).
- Multifactorial logistic regression used to identify independent risk factors.
Main Results:
- Duration of fever, procalcitonin (PCT), and lactate dehydrogenase (LDH) were significantly higher in the mucus plug group.
- No significant differences observed in sex, age, WBC count, or C-reactive protein (CRP).
- Logistic regression identified duration of fever (≥6.5 days), PCT (≥0.705 ng/ml), and LDH (≥478.5 U/L) as independent risk factors.
Conclusions:
- Duration of fever, PCT, and LDH levels are independent risk factors for mucus plug formation in pediatric ADV pneumonia.
- These findings can assist clinicians in predicting and managing mucus plugs.
- Early detection of these indicators may improve patient outcomes.
Background:
The risk factors for mucus plug in children with adenovirus (ADV) pneumonia.
Methods And Materials:
A retrospective analysis was conducted of children diagnosed ADV pneumonia and underwent fiberoptic bronchoscopy admitted to the Xiamen Children's Hospital from September 2018 to September 2021.The patients were divided into a mucus plug group (39 cases) and a non-mucus plug group (53 cases). The children's data including sex, age, clinical presentation, laboratory test parameters, imaging and bronchoscopic data were collected. The risk factors for the development of airway mucus plug were analysed by multifactorial logistic regression.
Results:
There were no statistically significant differences in sex, age, fever, hospitalization days, mixed infection, white blood cells (WBC) count, percentage of neutrophils (NE%), C-reactive protein(CRP), and D-dimer (all P > 0.05); Thermal range, procalcitonin (PCT), lactate dehydrogenase (LDH), Pleural effusion and associated decreased breath sounds was significantly higher in mucus plug group than in non-mucus plug group, and the differences were statistically significant (all P < 0.05); multifactorial logistic regression analysis showed that the duration of fever, PCT, and LDH were independent risk factors for the formation of mucus plugs. The critical values of ROC curves were pyroprocedure ≥ 6.5 d, PCT ≥ 0.705 ng/ml and LDH ≥ 478.5 U/L.
Conclusion:
Duration of fever, PCT and LDH levels were the independent risk factors for the formation of an airway mucus plug in children with ADV pneumonia.
More Related Videos
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
11:32Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Related Concept Videos
01:30Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
01:30Pneumonia III: Complications and Assessment
01:30Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
01:17Pulmonary Cycle: Exhalation
01:29Asthma-I: Introduction