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Updated: Jul 10, 2025

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

Ultra-Sensitive Portable Visual Paper-Based Viral Molecularly Imprinted Sensor without Autofluorescence Interference.

Hang Gong¹, Siyu Chen², Li Tang²

¹College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.

Analytical Chemistry

|November 18, 2023

Summary

This study introduces a low-cost, paper-based sensor for detecting influenza virus (H5N1) and Hepatitis B Virus (HBV). The ultrasensitive sensor offers visual, semi-quantitative results, aiding in rapid epidemic control.

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Last Updated: Jul 10, 2025

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Area of Science:

Biomedical Engineering
Nanotechnology
Infectious Disease Detection

Background:

Early virus detection is crucial for controlling epidemics.
Existing methods can be costly and time-consuming.
Simultaneous detection of multiple viruses remains a challenge.

Purpose of the Study:

To develop an ultrasensitive, paper-based sensor for simultaneous detection of H5N1 and HBV.
To create a low-cost, portable, and visually interpretable diagnostic tool.
To enable rapid, point-of-care virus identification.

Main Methods:

Utilized molecular imprinting on a paper substrate for virus recognition.
Employed aptamer-functionalized persistent luminescent nanoparticles as signal probes.
Designed a sandwich-type assay for dual virus detection.

Main Results:

Achieved a detection limit of 16.0 aM for H5N1 and 129 fM for HBV.
Demonstrated visual, semi-quantitative detection of both viruses.
The sensor is low-cost, portable, and easy to use.

Conclusions:

The developed sensor offers high sensitivity and specificity for H5N1 and HBV detection.
This technology provides a new avenue for virus epidemic prevention and control.
The portable, visual sensor facilitates self-service detection, reducing healthcare burdens and infection risks.